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abstract::The Cdc25 dual specificity phosphatases have central roles in coordinating cellular signalling processes and cell proliferation. It has been reported that an improper amplification or activation of these enzymes is a distinctive feature of a number of human cancers, including breast cancers. Thus, the inhibition of Cd...
journal_title:ChemMedChem
pub_type: 杂志文章
doi:10.1002/cmdc.200500092
更新日期:2006-05-01 00:00:00
abstract::A synthetic concept is presented that allows the construction of peptide isostere libraries through polymer-supported C-acylation reactions. A phosphorane linker reagent is used as a carbanion equivalent; by employing MSNT as a coupling reagent, the C-acylation can be conducted without racemization. Diastereoselective...
journal_title:ChemMedChem
pub_type: 杂志文章
doi:10.1002/cmdc.200500027
更新日期:2006-04-01 00:00:00
abstract::The first series of 2'-substituted 2-(3'-carboxybicyclo[1.1.1]pentyl)glycine derivatives, (2R)- and (2S)-(2',2'-dichloro-3'-carboxybicyclo[1.1.1]pentyl)glycine (10) and (11), and 2-(2'-chloro-3'-carboxybicyclo[1.1.1]pentyl)glycine (12) were synthesized and evaluated as mGluR ligands. Compounds 11 and 12 were shown to ...
journal_title:ChemMedChem
pub_type: 杂志文章
doi:10.1002/cmdc.200500071
更新日期:2006-03-01 00:00:00
abstract::TIBO- and TBO-like sulfone derivatives 1 and 2 were designed, synthesized, and tested for their ability to block the replication cycle of HIV-1 in infected cells. The anti-HIV-1 activities of sulfones 3, which were intermediates in the syntheses of 1 and 2, were also evaluated. Surprisingly, the sulfone analogues of T...
journal_title:ChemMedChem
pub_type: 杂志文章
doi:10.1002/cmdc.200500020
更新日期:2006-01-01 00:00:00
abstract::Modern organizations conducting drug-discovery programs frequently apply high-throughput screening to generate novel hit structures for the indications of interest. Systematic hit-to-lead processes have been established at most pharmaceutical companies to ensure a smooth conversion of hits into high-quality lead struc...
journal_title:ChemMedChem
pub_type: 杂志文章
doi:10.1002/cmdc.200500031
更新日期:2006-01-01 00:00:00